Interleukin-6 human I1395 from MilliporeSigma

Product Specs
ItemInterleukin-6 human
CompanyMilliporeSigma
Price Pricing Info Supplier Page View Company Product Page
Catalog NumberI1395
Molecular Weight26 kDa
Specieshuman
Molecule NameACE, ECE1, Ace
NCBI Full Gene Nameangiotensin I converting enzyme, endothelin converting enzyme 1
NCBI Gene AliasesDcp1, StsRR92, DCP1, CD143, ACE1, ECE, DCP
Applicationsmammalian cell culture
FormatLyophilized from a 0.2 µm filtered solution of phosphate buffer saline (PBS), pH 7.4, containing 500 µg bovine serum albumin
Quantity10µG, 10µG, 50µG, 50µG

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MilliporeSigma

400 Summit Drive

Burlington, Massachusetts 01803

United States

Phone: (800)-645-5476
(800)-645-5439

Company Profile

Website: www.SigmaAldrich.com/

(1) The Impact of Hydroxychloroquine on Primary Feto-Placental Endothelial Cells from Healthy and Early-Onset Preeclamptic PlacentasInternational Journal of Molecular SciencesJune 30, 2023Maja Gajić, Bianca Schröder-Heurich, Monika Horvat Mercnik, Mila Cervar-Zivkovic, Christian Wadsack, Frauke von Versen-Höynck, Karoline Mayer-PickelGermany) to the concentration of 10 mg/mL. Cytokines: TNF-α (H8916, Merck, Darmstadt, Germany), IL-6 (I1395, Merck, Darmstadt, Germany) and recombinant human IL-1β (200-Q1B, PeproTech, Cranbury, NJ, USA) were

(2) Airway surface hyperviscosity and defective mucociliary transport by IL-17/TNF-α are corrected by beta-adrenergic stimulusJCI InsightNovember 22, 2022Daniela Guidone, Martina Buccirossi, Paolo Scudieri, Michele Genovese, Sergio Sarnataro, Rossella De Cegli, Federico Cresta, Vito Terlizzi, Gabrielle Planelles, Gilles Crambert, et al.Sigma-Aldrich), IFN-γ (10 ng/mL, I3265, Sigma-Aldrich), IL-1β (10 ng/mL H6291, Sigma-Aldrich), or IL-6 (10 ng/mL, I1395, Sigma-Aldrich). Immunofluorescence of cultured epithelia. Snapwell supports carrying differentiated

(3) Isolation of human and mouse myeloid-derived suppressor cells for metabolic analysisSTAR protocolsJune 17, 2022Choi JE, MacDonald CR, Gandhi N, Das G, Repasky EA, Mohammadpour H.Red,MilliporeSigma,Catalog # P3532 Mouse IL-6,MilliporeSigma,Catalog # I9646 Human IL-6,MilliporeSigma,Catalog # I1395 Mouse GM-CSF,BioLegend,Catalog # 713704 Human GM-CSF,BioLegend,Catalog # 713604 Detachin Cell Detachment

(4) Akt-Dependent Glycolysis-Driven Lipogenesis Supports Proliferation and Survival of Human Pulmonary Arterial Smooth Muscle Cells in Pulmonary HypertensionFrontiers in medicineJanuary 1, 2022Jiang L, Goncharov DA, Shen Y, Lin D, Chang B, Pena A, DeLisser H, Goncharova EA, Kudryashova TV.Cell Signaling (Danvers, MA, United States). Inhibitors and Activators 2-Deoxy-D-glucose (2-DG, D6134), IL-6 (I1395), PDGF-BB (GF149), and Akt inhibitor VIII (SIAL-124018) were purchased from Millipore Sigma (St. Louis,

(5) Dihydromyricetin ameliorates osteogenic differentiation of human aortic valve interstitial cells by targeting c-KIT/interleukin-6 signaling pathwayFrontiers in pharmacologyJanuary 1, 2022Zhang S, Fan L, Wang Y, Xu J, Shen Q, Xie J, Zeng Z, Zhou T.final concentration in OM) was used to induce phosphorylation of c-KIT. IL-6 (Sigma–Aldrich, Catalog# I1395; at 50 ng/ml final concentration in OM) was used to explore the underlying mechanism of the DHM-mediated

(6) Analytical and clinical evaluation of a novel assay for measurement of interleukin 6 in human whole blood samplesJournal of Clinical Laboratory AnalysisNovember 1, 2021Zhicheng Ye, Niuniu Dong, Keqing Liang, Haixia Hu, Jin Xulimit of detection. A high‐concentration pool was prepared by spiking recombinant IL‐6 (Sigma Aldrich, product no. I1395) into an aliquot of the pooled sample to a final concentration of ~45,000 pg/ml. Six different analyte

(7) β2-adrenergic receptor signaling regulates metabolic pathways critical to myeloid-derived suppressor cell function within the TMECell reportsOctober 26, 2021Mohammadpour H, MacDonald CR, McCarthy PL, Abrams SI, Repasky EA.C57/BL6 mice in 100 μLs of PBS. METHOD DETAILS Reagents used Mouse (Catalog I9646) and human (Catalog I1395) IL-6 were from MilliporeSigma. Mouse (Catalog 713704) and human (Catalog 713604) GM-CSF and mouse (Catalog

(8) Silencing of ISLR inhibits tumour progression and glycolysis by inactivating the IL‑6/JAK/STAT3 pathway in non‑small cell lung cancerInternational Journal of Molecular MedicineOctober 26, 2021Peng Zhang, Zhen Li, Guangming Yangconstant-temperature incubator (Thermo Fisher Scientific, Inc.) with 5% CO2 at 37°C. Human recombinant IL-6 (cat. no. I1395-50UG; Sigma-Aldrich; Merck KGaA) was dissolved in PBS to a concentration of 100 µg/ml as a stock solution

(9) Stromal induction of BRD4 phosphorylation Results in Chromatin Remodeling and BET inhibitor Resistance in Colorectal CancerNature communicationsJuly 21, 2021Wang W, Tang YA, Xiao Q, Lee WC, Cheng B, Niu Z, Oguz G, Feng M, Lee PL, Li B, et al.following recombinant proteins were used in cell treatments: Recombinant human IL-6 (Sigma-Aldrich, Cat#I1395), Recombinant human IL-8 (PeproTech, Cat#200-08), human TNFα (PeproTech, Cat#300-01 A), human IL-1β

(10) Tumor exposed-lymphatic endothelial cells promote primary tumor growth via IL6Cancer LettersJanuary 28, 2021Maureen Van de Velde, Marie Ebroin, Tania Durré, Marc Joiret, Lionel Gillot, Silvia Blacher, Liesbet Geris, Frédéric Kridelka, Agnès Noel(15140-122) (all from Thermofisher, MA). Serum-starved tumor cells were treated with recombinant human IL6 (I1395, Sigma, Belgium) and a neutralizing antibody against IL6 (2.5 μg/ml, MAB 2061, R&D Systems, MN). LEC

(11) Iron overload inhibits BMP/SMAD and IL-6/STAT3 signaling to hepcidin in cultured hepatocytesPloS oneJanuary 1, 2021Charlebois E, Pantopoulos K.from Sigma-Aldrich. Following recombinant proteins were used: murine IL-6 (#5216, Cell Signaling), human IL-6 (#I1395, Sigma-Aldrich), human BMP6 (#507-BP, R&D Systems), and human holo-transferrin (#T4132, Sigma). Salicylaldehyde

(12) YAP and TAZ protect against white adipocyte cell death during obesityNature communicationsOctober 28, 2020Wang L, Wang S, Shi Y, Li R, Günther S, Ong YT, Potente M, Yuan Z, Liu E, Offermanns S.wortmannin (catalog number W3144), latrunculin B (catalog number 428020), and IL-6 (catalog number I1395) were from Sigma-Aldrich. SC514 was from Santa Cruz Biotechnology (catalog number 354812-17-2). SP600125

(13) Delineating Astrocytic Cytokine Responses in a Human Stem Cell Model of Neural TraumaJournal of NeurotraumaJanuary 1, 2020Eric Peter Thelin et al.control samples (technical repeats). Human recombinant IL-1β (#11457756001), IL-4 (#I4269), IL-6 (#I1395), IL-10 (#IL010), and TNF (#T6674) (all from Merck, Kenilworth, NJ) were each sourced as lyophilized

(14) Impact of Proinflammatory Cytokines on the Virulence of Uropathogenic Escherichia coliFrontiers in MicrobiologyMay 9, 2019Ulrik Engelsöy, Ignacio Rangel, Isak DemirelCaCl2, and 0.25% Casamino Acids) with or without the presence of TNF-α (T6674), IL-1β (I9401), IL-6 (I1395), IL-8 (I1645) or IFN-γ (SRP3058) (0.5, 1, 10, 20 or 40 ng/ml, all from Sigma-Aldrich, St. Louis, MO,

(15) Hindlimb Ischemia Impairs Endothelial Recovery and Increases Neointimal Proliferation in the Carotid ArteryScientific reportsJanuary 15, 2018Sorrentino S, Iaconetti C, De Rosa S, Polimeni A, Sabatino J, Gareri C, Passafaro F, Mancuso T, Tammè L, Mignogna C, et al.investigate the effect of pro-inflammatory cytokine on miR-16 expression, HUVECs were incubated with IL-6 (I1395–10UG; Sigma Aldrich), IL-8 (I1645–10UG; Sigma Aldrich), IL-1β (I9401–5UG; Sigma Aldrich), and TNF-α

(16) Norcantharidin inhibits IL-6-induced epithelial-mesenchymal transition via the JAK2/STAT3/TWIST signaling pathway in hepatocellular carcinoma cellsOncology ReportsFebruary 1, 2017Yebo Gao, Weidong Li, Rui Liu, Qiujun Guo, Jie Li, Yanju Bao, Honggang Zheng, Shulong Jiang, Baojin Huadiluted to a concentration of 0.5 µM in culture medium before use (DMSO <1%). Human recombinant IL-6 (#I1395-50UG; Sigma-Aldrich) was dissolved in phosphate-buffered saline (PBS) to a concentration of 100 µg/ml

(17) Exposure to concentrated ambient fine particulate matter disrupts vascular endothelial cell barrier function via the IL-6/HIF-1α signaling pathwayFEBS open bioJuly 1, 2016Dai J, Sun C, Yao Z, Chen W, Yu L, Long M.KeyGen Biotech (Nanjing, China). TRIzol was obtained from Invitrogen (CA, USA). Recombinant human IL‐6 (I1395) was obtained from Sigma‐Aldrich (St. Louis, MO, USA). The siRNA duplex for HIF‐1α was synthesized by

(18) Insufficiency of phosphatidylethanolamine N-methyltransferase is risk for lean non-alcoholic steatohepatitisScientific ReportsApril 1, 2016Atsuko Nakatsuka et al.glucose (25 mM), 100 nM insulin (I9278, SIGMA), 250 μM palmitate (P0500, SIGMA), and 20 ng/ml IL-6 (I1395, SIGMA). For the preparation of palmitate stock solution, 500 mM palmitate in DMSO was diluted to 5

(19) Human Head and Neck Squamous Cell Carcinoma-Associated Semaphorin 4D Induces Expansion of Myeloid-Derived Suppressor CellsJournal of immunology (Baltimore, Md. : 1950)February 1, 2016Younis RH, Han KL, Webb TJ.Recombinant human GM-CSF (catalog no. 215-GM-010) (R&D Systems Minneapolis, MN) and IL-6 recombinant human (catalog no. I1395) from (Sigma-Aldrich) were also used. Griess reagent (catalog no. G2930) (Promega, Madison, WI) was

(20) Downregulation of duodenal SLC transporters and activation of proinflammatory signaling constitute the early response to high altitude in humansAmerican journal of physiology. Gastrointestinal and liver physiologyOctober 1, 2014Wojtal KA, Cee A, Lang S, Götze O, Frühauf H, Geier A, Pastor-Anglada M, Torres-Torronteras J, Martí R, Fried M, et al.anti-HIF-2␣ was purchased from Abcam (Cambridge, UK). Human recombinant IFN-␥ (IFG40012) and IL-6 (I1395), and CoCl2 (15862) were purchased from SigmaAldrich (Buchs, Switzerland). FM19G11 (sc-364490) and FR180204 (sc-203945)

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Interleukin-6 human from MilliporeSigma

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Interleukin-6 human from MilliporeSigma

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